NEMBUTAL SODIUM POWDER (PENTOBARBITAL)
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What is NEMBUTAL SODIUM POWDER (PENTOBARBITAL) ?
NEMBUTAL SODIUM POWDER is used for the short-term treatment of insomnia, to help manage seizures, before surgery or medical procedures as a preanesthetic drug, or to promote a medically induced coma.
The most easily obtainable form today is vials of Nembutal Sodium Solution (pentobarbital sodium injection), a sterile solution for intravenous or intramuscular injection, typically used for animal anaesthesia or euthanasia. Each mL contains pentobarbital sodium 50 mg or 100 mg, in a vehicle of approximately propylene glycol, 40%, alcohol, 10% and water for injection, to volume. The pH is adjusted to approximately 9.5 with hydrochloric acid and/or sodium hydroxide. The range of actual pentobarbital sodium in a vial may vary between 3 g to 15 g, although 6 g seems common. The containers come in a clear vial typical for sterile solutions, and should have an untouched protective metal cap if unopened, and be labelled clearly with due date. Dignitas also use some sort of solution, albeit with a higher concentration. The solution may be taken intravenously, for very quick effect as in capital punishment, or orally, see below.
NEMBUTAL SODIUM POWDER is a short-acting barbiturate, chemically designated as sodium 5-ethyl-5-(1-methylbutyl) barbiturate. This is one of the reasons for being more suitable for suicide than longer-acting barbiturates such as phenobarbital.
Contraindictions and precautions
NEMBUTAL SODIUM POWDER is contraindicated in patients with a history of barbiturate hypersensitivity. Injectable solutions may also contain propylene glycol and should be avoided in patients with a hypersensitivity to propylene glycol. Barbiturates can cause severe and potentially fatal reactions that are preceded by skin eruptions. Therapy should be prescribed only after critical benefit-to-risk appraisal in patients with a history of adverse hematologic (i.e., agranulocytosis), hypersensitivity, or other adverse reactions to barbiturate or other anticonvulsants. Hypersensitivity reactions have been reported in patients who previously experienced hydantoin hypersensitivity (e.g., phenytoin) or carbamazepine hypersensitivity. Estimates of cross-sensitivity vary, but may range from 30% to 80%. Phenytoin, carbamazepine, and NEMBUTAL SODIUM POWDER are all metabolized to hydroxylated aromatic compounds via the cytochrome P450 hepatic oxidative enzymes; arene oxide intermediates are formed during metabolism and are thought to be responsible for cross-sensitivity among these anticonvulsants in susceptible individuals. Some individuals may have a reduced ability to detoxify the intermediate toxic metabolites (e.g., arene oxides) of these anticonvulsants, which may be genetically mediated. However, studies of familial reactions have also shown that allergies to 1 anticonvulsant may not translate to allergies to others. There is no way to predict with certainty which patients will exhibit cross-sensitivity.Contact us for more information.
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